Mitochondrial ribosomal protein L10

📅 آخر تحديث: ٣ أغسطس ٢٠٢٦
✍️ نُشر في: ٣ أغسطس ٢٠٢٦
الموسوعة الحرة

39S ribosomal protein L10, mitochondrial is a protein that in humans is encoded by the MRPL10gene.[5][6]

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. Sequence analysis identified two transcript variants that encode different isoforms. A pseudogene corresponding to this gene is found on chromosome 5q.[6]

References

  1. 123GRCh38: Ensembl release 89: ENSG00000159111–Ensembl, May 2017
  2. 123GRCm38: Ensembl release 89: ENSMUSG00000001445–Ensembl, May 2017
  3. ↑"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ↑"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ↑Koc EC, Burkhart W, Blackburn K, Moyer MB, Schlatzer DM, Moseley A, Spremulli LL (Nov 2001). "The large subunit of the mammalian mitochondrial ribosome. Analysis of the complement of ribosomal proteins present". J Biol Chem. 276 (47): 43958–69. doi:10.1074/jbc.M106510200. PMID 11551941.
  6. 12"Entrez Gene: MRPL10 mitochondrial ribosomal protein L10".

Further reading

  • نظرة عامة على جميع المعلومات الهيكلية المتاحة في PDB لـ UniProt : Q7Z7H8 (بروتين ريبوسومي 39S L10، ميتوكوندريا) في PDBe-KB .